Case Studies Sartorius Accelerates Cell Line and Process Development by a Factor of 3

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	Sartorius Accelerates Cell Line and Process Development by a Factor of 3

Sartorius Accelerates Cell Line and Process Development by a Factor of 3

Technology Category	Platform as a Service (PaaS) - Data Management Platforms Application Infrastructure & Middleware - Data Exchange & Integration
Applicable Industries	Pharmaceuticals Healthcare & Hospitals
Applicable Functions	Product Research & Development Quality Assurance
Use Cases	Predictive Maintenance Process Control & Optimization Inventory Management
Services	Data Science Services System Integration
Challenge	Sartorius Stedim Biotech, a leading provider of instruments, technologies, and expertise for the development and production of biopharmaceuticals, was facing a major data processing bottleneck due to its rapid growth. The company was primarily using Excel and paper for data management, which became increasingly challenging as the number of cell lines they were handling per year grew. The manual integration and correlation of data for in-project and cross-project analyses were extremely labor-intensive and time-consuming. Sartorius needed a central platform to streamline and digitalize cell line and process development, expand automation, and improve throughput and efficiency. They were looking for a solution that could handle their specific workflow requirements, automate laboratory operations, enable a transition to a fully paperless laboratory, and enhance scalability to support their continued growth. Read More
About Customer	Sartorius Stedim Biotech is a leading global technology provider and Contract Development & Manufacturing Organization (CDMO) for the biopharmaceutical industry. The company provides cell lines, cell banks, and bioanalytical services. Sartorius' solutions are used by biopharma and biotech companies to safely and economically develop and produce innovative drugs. In 2015, Sartorius expanded their bioprocess development portfolio to include cell line development and upstream and downstream process development services for large-scale protein production of biopharmaceuticals in mammalian cells (CHO). They support their customers in the development of processes for the production of mAbs, bispecific antibodies, Fc-fusion proteins, enzymes, vaccines, and biosimilars. More recently, Sartorius has rapidly expanded into the cell & gene therapy (CGT) and the mRNA markets. Read More
Solution	Sartorius chose to implement the Genedata Bioprocess enterprise workflow platform as it met all their requirements and was the only commercial-off-the-shelf (COTS) solution that included all required logic. The platform was able to be directly integrated into Sartorius' wide array of laboratory equipment, facilitating seamless transfer of data and samples along the full development workflow. The Genedata platform seamlessly interacts with Sartorius’ screening robotics systems, bioreactors such as ambr15 and ambr250, BioStats, as well as analytics devices such as Octet. Today, Genedata Bioprocess is the digital workflow backbone of Sartorius’ quickly growing cell line and process development organization. It supports Sartorius’ unique and proprietary processes including CHO transfections, expression vectors, plasmid generation and optimization, media development, and tailored upstream process design workflows. Read More Log in to view content
Contents

Technology Category

Platform as a Service (PaaS) - Data Management Platforms

Application Infrastructure & Middleware - Data Exchange & Integration

Applicable Industries

Pharmaceuticals

Healthcare & Hospitals

Applicable Functions

Product Research & Development

Quality Assurance

Use Cases

Predictive Maintenance

Process Control & Optimization

Inventory Management

Services

Data Science Services

System Integration

Challenge

Sartorius Stedim Biotech, a leading provider of instruments, technologies, and expertise for the development and production of biopharmaceuticals, was facing a major data processing bottleneck due to its rapid growth. The company was primarily using Excel and paper for data management, which became increasingly challenging as the number of cell lines they were handling per year grew. The manual integration and correlation of data for in-project and cross-project analyses were extremely labor-intensive and time-consuming. Sartorius needed a central platform to streamline and digitalize cell line and process development, expand automation, and improve throughput and efficiency. They were looking for a solution that could handle their specific workflow requirements, automate laboratory operations, enable a transition to a fully paperless laboratory, and enhance scalability to support their continued growth.

About Customer

Sartorius Stedim Biotech is a leading global technology provider and Contract Development & Manufacturing Organization (CDMO) for the biopharmaceutical industry. The company provides cell lines, cell banks, and bioanalytical services. Sartorius' solutions are used by biopharma and biotech companies to safely and economically develop and produce innovative drugs. In 2015, Sartorius expanded their bioprocess development portfolio to include cell line development and upstream and downstream process development services for large-scale protein production of biopharmaceuticals in mammalian cells (CHO). They support their customers in the development of processes for the production of mAbs, bispecific antibodies, Fc-fusion proteins, enzymes, vaccines, and biosimilars. More recently, Sartorius has rapidly expanded into the cell & gene therapy (CGT) and the mRNA markets.

Solution

Sartorius chose to implement the Genedata Bioprocess enterprise workflow platform as it met all their requirements and was the only commercial-off-the-shelf (COTS) solution that included all required logic. The platform was able to be directly integrated into Sartorius' wide array of laboratory equipment, facilitating seamless transfer of data and samples along the full development workflow. The Genedata platform seamlessly interacts with Sartorius’ screening robotics systems, bioreactors such as ambr15 and ambr250, BioStats, as well as analytics devices such as Octet. Today, Genedata Bioprocess is the digital workflow backbone of Sartorius’ quickly growing cell line and process development organization. It supports Sartorius’ unique and proprietary processes including CHO transfections, expression vectors, plasmid generation and optimization, media development, and tailored upstream process design workflows.

Impact #1	With Genedata Bioprocess in place, Sartorius has significantly increased operational efficiency and reduced costs. The platform is used in the daily operations of all cell line and process development teams to monitor and assess key process and quality parameters such as confluence, titers, monoclonality, and viable cell density.
Impact #2	By providing project progress tracking in real-time, Sartorius can now seamlessly and continuously monitor all resources across cell line and process development projects, enabling systematic resource planning and streamlining operations.
Impact #3	The Genedata platform has also increased process quality. By automating data transfer and documentation of critical data, Sartorius has minimized errors and ensured data integrity.

Impact #1

With Genedata Bioprocess in place, Sartorius has significantly increased operational efficiency and reduced costs. The platform is used in the daily operations of all cell line and process development teams to monitor and assess key process and quality parameters such as confluence, titers, monoclonality, and viable cell density.

Impact #2

By providing project progress tracking in real-time, Sartorius can now seamlessly and continuously monitor all resources across cell line and process development projects, enabling systematic resource planning and streamlining operations.

Impact #3

The Genedata platform has also increased process quality. By automating data transfer and documentation of critical data, Sartorius has minimized errors and ensured data integrity.

Benefit #1	Sartorius has been able to triple their productivity.
Benefit #2	A Sartorius-internal assessment showed that the time saved having central access to digital documentation is more than 30%.

Benefit #1

Sartorius has been able to triple their productivity.

Benefit #2

A Sartorius-internal assessment showed that the time saved having central access to digital documentation is more than 30%.

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Overview

Sartorius Accelerates Cell Line and Process Development by a Factor of 3

Operational Impact

Quantitative Benefit