Case Studies CSL transforms automated micro-purification with accelerated planning & data processing

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	CSL transforms automated micro-purification with accelerated planning & data processing

CSL transforms automated micro-purification with accelerated planning & data processing

Technology Category	Platform as a Service (PaaS) - Data Management Platforms Platform as a Service (PaaS) - Connectivity Platforms
Applicable Industries	Healthcare & Hospitals Life Sciences
Applicable Functions	Product Research & Development Quality Assurance
Use Cases	Predictive Maintenance Process Control & Optimization Real-Time Location System (RTLS)
Services	Cloud Planning, Design & Implementation Services Data Science Services
Challenge	CSL set a goal of doubling the throughput of experimentation via robotics, automation & digital connectivity without a significant increase in headcount by 2030. The CSL Purification Team was looking for a solution that would enable scientists to plan and execute micro-scale purification experiments without the need to write code, ensuring their scientists could increase their throughput while improving the quality of their results. The team faced obstacles such as low uptake of automation and complicated scripting, low device utilization in lab environments, and manual management of experimental workflows & associated data. The team required a tool that would help them standardize their workflow design, execution, and data analysis processes for micro-scale purification experiments and easily transfer knowledge from one site to the next. Read More
About Customer	CSL is a leading global biotechnology company with a dynamic portfolio of lifesaving medicines, including those that treat hemophilia and immune deficiencies, vaccines to prevent influenza, and therapies in iron deficiency, dialysis, and nephrology. Since its beginnings in 1916, CSL has been driven by its promise to save lives using the latest technologies. Today, CSL – including its three businesses, CSL Behring, CSL Seqirus, and CSL Vifor – provides lifesaving products to patients in more than 100 countries and employs 30,000 people. CSL’s unique combination of commercial strength, R&D focus, and operational excellence enables the company to identify, develop and deliver innovations so its patients can live life to the fullest. Read More
Solution	The collaboration between CSL and Synthace aligned with the CSL Purification Team's goal of digital connectivity, robotics, and automation to improve process development efficiencies within the CSL Purification Team. The drag-and-drop design elements of Workflow Builder translate the CSL Purification Team's human-language directions into complex robot instructions with no custom scripting required. The in-silico simulation allows scientists to understand how their designed experiment would be physically executed on the liquid handling platform, tracking the liquids across the workflow. Synthace catches errors like impossible liquid transfers or insufficient deck space. This allows CSL Purification Team scientists to catch errors at the design stage - a great time saver, since trial runs are no longer necessary to ensure the script was set up properly ahead of the experiment. The plate reader data collected in the experiment is automatically uploaded, aligned with the liquid handling data, and analyzed by the Synthace platform without the need for manual intervention. Read More Log in to view content
Contents

Technology Category

Platform as a Service (PaaS) - Data Management Platforms

Platform as a Service (PaaS) - Connectivity Platforms

Applicable Industries

Healthcare & Hospitals

Life Sciences

Applicable Functions

Product Research & Development

Quality Assurance

Use Cases

Predictive Maintenance

Process Control & Optimization

Real-Time Location System (RTLS)

Services

Cloud Planning, Design & Implementation Services

Data Science Services

Challenge

CSL set a goal of doubling the throughput of experimentation via robotics, automation & digital connectivity without a significant increase in headcount by 2030. The CSL Purification Team was looking for a solution that would enable scientists to plan and execute micro-scale purification experiments without the need to write code, ensuring their scientists could increase their throughput while improving the quality of their results. The team faced obstacles such as low uptake of automation and complicated scripting, low device utilization in lab environments, and manual management of experimental workflows & associated data. The team required a tool that would help them standardize their workflow design, execution, and data analysis processes for micro-scale purification experiments and easily transfer knowledge from one site to the next.

About Customer

CSL is a leading global biotechnology company with a dynamic portfolio of lifesaving medicines, including those that treat hemophilia and immune deficiencies, vaccines to prevent influenza, and therapies in iron deficiency, dialysis, and nephrology. Since its beginnings in 1916, CSL has been driven by its promise to save lives using the latest technologies. Today, CSL – including its three businesses, CSL Behring, CSL Seqirus, and CSL Vifor – provides lifesaving products to patients in more than 100 countries and employs 30,000 people. CSL’s unique combination of commercial strength, R&D focus, and operational excellence enables the company to identify, develop and deliver innovations so its patients can live life to the fullest.

Solution

The collaboration between CSL and Synthace aligned with the CSL Purification Team's goal of digital connectivity, robotics, and automation to improve process development efficiencies within the CSL Purification Team. The drag-and-drop design elements of Workflow Builder translate the CSL Purification Team's human-language directions into complex robot instructions with no custom scripting required. The in-silico simulation allows scientists to understand how their designed experiment would be physically executed on the liquid handling platform, tracking the liquids across the workflow. Synthace catches errors like impossible liquid transfers or insufficient deck space. This allows CSL Purification Team scientists to catch errors at the design stage - a great time saver, since trial runs are no longer necessary to ensure the script was set up properly ahead of the experiment. The plate reader data collected in the experiment is automatically uploaded, aligned with the liquid handling data, and analyzed by the Synthace platform without the need for manual intervention.

Impact #1	Significant time savings in the automation of end-to-end micro-scale purification experiments on the Tecan Evo liquid-handling platform.
Impact #2	Increased automation usage and throughput within the lab.
Impact #3	Enabled the design of increasingly complex workflows by less experienced team members.

Impact #1

Significant time savings in the automation of end-to-end micro-scale purification experiments on the Tecan Evo liquid-handling platform.

Impact #2

Increased automation usage and throughput within the lab.

Impact #3

Enabled the design of increasingly complex workflows by less experienced team members.

Benefit #1	Up to 60% time savings on end-to-end micro-scale purification workflows.
Benefit #2	Up to 50% increase in automation usage in the lab.

Benefit #1

Up to 60% time savings on end-to-end micro-scale purification workflows.

Benefit #2

Up to 50% increase in automation usage in the lab.

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Overview

CSL transforms automated micro-purification with accelerated planning & data processing

Operational Impact

Quantitative Benefit