Case Studies CRUK Cancer Therapeutics Unit at the Institute of Cancer Research – Case Study Part IV: A Dotmatics Project Environment

Edit This Case Study Record

	CRUK Cancer Therapeutics Unit at the Institute of Cancer Research – Case Study Part IV: A Dotmatics Project Environment

CRUK Cancer Therapeutics Unit at the Institute of Cancer Research – Case Study Part IV: A Dotmatics Project Environment

Technology Category	Platform as a Service (PaaS) - Data Management Platforms
Applicable Industries	Healthcare & Hospitals Life Sciences
Applicable Functions	Product Research & Development Quality Assurance
Services	Data Science Services System Integration
Challenge	The Cancer Research UK Cancer Therapeutics Unit (CTU) at The Institute of Cancer Research, the largest academic cancer drug discovery and development group worldwide, was facing a challenge in managing its drug discovery projects. There was no cheminformatics platform in place at the CTU to consolidate and provide quick and easy access to data, which had led to only certain people having full access to the project data landscape. This was limiting the ability of the team to freely access data, analyze it, see the correlations, and then being able to use those correlations to determine what direction to head in – all in real time. Moreover, it was hindering the opportunity for everyone to review the data, challenge discrepancies, spot outliers and have input into what that next step should be. Read More
About Customer	The Cancer Research UK Cancer Therapeutics Unit (CTU) at The Institute of Cancer Research is the largest academic cancer drug discovery and development group worldwide. Since 2005, the CTU, together with its collaborators, has discovered 17 preclinical development candidates; seven of which are currently in clinical trials. The research teams that make up the CTU, and in particular the Chemistry department within the Unit, all rely heavily on the Dotmatics informatics platform. Serving as the central point of convergence for the 163 people who staff the Unit, Dotmatics Gateway is a document management solution that holds all project information and standard operating procedures. The CTU currently holds 115 seats for Browser, with levels of access that vary from full, director-level access to read-only access for specific projects. Read More
Solution	The CTU implemented the Dotmatics integrated suite of scientific informatics solutions to manage all its drug discovery projects. The Dotmatics Gateway, a document management solution, holds all project information and standard operating procedures. All project data is managed by and accessible through Dotmatics Browser, a flexible web-based query and reporting tool that consolidates all disparate databases into one central resource. The CTU can assign a set number of seats to named collaborators within the external organisation who are then provided with a security code. This code means that only specific projects and their associated data and documentation can be accessed by the external organisation, and both the named collaborators and the assigned level of project access can be easily amended by the CTU at any time. When new assay data comes in to the CTU it is immediately uploaded via Dotmatics Studies, a web-based data management solution that enables the creation, capture, analysis and storage of scientific data. Read More Log in to view content
Contents

Technology Category

Platform as a Service (PaaS) - Data Management Platforms

Applicable Industries

Healthcare & Hospitals

Life Sciences

Applicable Functions

Product Research & Development

Quality Assurance

Services

Data Science Services

System Integration

Challenge

The Cancer Research UK Cancer Therapeutics Unit (CTU) at The Institute of Cancer Research, the largest academic cancer drug discovery and development group worldwide, was facing a challenge in managing its drug discovery projects. There was no cheminformatics platform in place at the CTU to consolidate and provide quick and easy access to data, which had led to only certain people having full access to the project data landscape. This was limiting the ability of the team to freely access data, analyze it, see the correlations, and then being able to use those correlations to determine what direction to head in – all in real time. Moreover, it was hindering the opportunity for everyone to review the data, challenge discrepancies, spot outliers and have input into what that next step should be.

About Customer

The Cancer Research UK Cancer Therapeutics Unit (CTU) at The Institute of Cancer Research is the largest academic cancer drug discovery and development group worldwide. Since 2005, the CTU, together with its collaborators, has discovered 17 preclinical development candidates; seven of which are currently in clinical trials. The research teams that make up the CTU, and in particular the Chemistry department within the Unit, all rely heavily on the Dotmatics informatics platform. Serving as the central point of convergence for the 163 people who staff the Unit, Dotmatics Gateway is a document management solution that holds all project information and standard operating procedures. The CTU currently holds 115 seats for Browser, with levels of access that vary from full, director-level access to read-only access for specific projects.

Solution

The CTU implemented the Dotmatics integrated suite of scientific informatics solutions to manage all its drug discovery projects. The Dotmatics Gateway, a document management solution, holds all project information and standard operating procedures. All project data is managed by and accessible through Dotmatics Browser, a flexible web-based query and reporting tool that consolidates all disparate databases into one central resource. The CTU can assign a set number of seats to named collaborators within the external organisation who are then provided with a security code. This code means that only specific projects and their associated data and documentation can be accessed by the external organisation, and both the named collaborators and the assigned level of project access can be easily amended by the CTU at any time. When new assay data comes in to the CTU it is immediately uploaded via Dotmatics Studies, a web-based data management solution that enables the creation, capture, analysis and storage of scientific data.

Impact #1	The Dotmatics platform has increased efficiency and enabled state-of-the-art data analysis in CTU, which in turn has driven improved medicinal chemistry design and decision making.
Impact #2	The platform has facilitated the relationship between the CTU research teams and their many external collaborators by allowing data to be shared confidentially and in real time.
Impact #3	The platform has enabled the CTU to work closely with collaborators and maintain one single repository for all data, regardless of whether it’s been generated at the CTU or externally.

Impact #1

The Dotmatics platform has increased efficiency and enabled state-of-the-art data analysis in CTU, which in turn has driven improved medicinal chemistry design and decision making.

Impact #2

The platform has facilitated the relationship between the CTU research teams and their many external collaborators by allowing data to be shared confidentially and in real time.

Impact #3

The platform has enabled the CTU to work closely with collaborators and maintain one single repository for all data, regardless of whether it’s been generated at the CTU or externally.

Benefit #1	Since 2005, the CTU has discovered 17 preclinical development candidates; seven of which are currently in clinical trials.

Benefit #1

Since 2005, the CTU has discovered 17 preclinical development candidates; seven of which are currently in clinical trials.

Download PDF Version

Overview

CRUK Cancer Therapeutics Unit at the Institute of Cancer Research – Case Study Part IV: A Dotmatics Project Environment

Operational Impact

Quantitative Benefit