Case Studies Building a Better DNA Assembly Line

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	Building a Better DNA Assembly Line

Building a Better DNA Assembly Line

Technology Category	Analytics & Modeling - Machine Learning Application Infrastructure & Middleware - Data Exchange & Integration Functional Applications - Product Lifecycle Management Systems (PLM)
Applicable Industries	Chemicals Food & Beverage Life Sciences
Applicable Functions	Product Research & Development Quality Assurance
Use Cases	Predictive Quality Analytics Process Control & Optimization Remote Control
Services	Cloud Planning, Design & Implementation Services Software Design & Engineering Services System Integration
Challenge	Arzeda needed a more efficient and less error-prone method to construct plasmids for producing designer proteins. The existing process was slow, resource-intensive, and prone to errors. The company faced a choice: either hire additional personnel to develop a new solution from scratch or integrate proven technologies from trusted vendors into a seamless, high-throughput DNA assembly platform. Read More
About Customer	Arzeda is a biotechnology company that designs and creates proteins for various industries, including life sciences, food, and chemicals. The company focuses on delivering important molecules by testing thousands of protein-producing plasmids. Arzeda aims to provide cost-effective and sustainable production of value-added specialty chemicals and ingredients. The company leverages computational protein design to build novel enzymes and develop new pathways, unlocking new opportunities for specialty chemicals, advanced materials, and health and nutrition products. Read More
Solution	Arzeda opted to integrate proven technologies from trusted vendors to create a seamless, high-throughput DNA assembly platform. They combined Twist Bioscience’s high-quality DNA fragments, TeselaGen’s DNA assembly design and laboratory automation software, and Labcyte’s Echo Liquid Handler. This integrated solution increased productivity, reduced consumable use, generated more accurate plasmid designs, and lowered costs. Twist Bioscience’s silicon-based DNA synthesis platform quickly and affordably produced high-quality synthetic DNA, which Arzeda combined into plasmids using sophisticated DNA assembly methods. TeselaGen’s software automated the process of DNA assembly, determining the best way to put plasmids together and which DNA fragments should be synthesized by Twist. The Labcyte Echo Liquid Handler used sound waves to move nanoliter-sized liquid droplets, making the process more efficient and reducing costs. Read More Log in to view content
Contents

Technology Category

Analytics & Modeling - Machine Learning

Application Infrastructure & Middleware - Data Exchange & Integration

Functional Applications - Product Lifecycle Management Systems (PLM)

Applicable Industries

Chemicals

Food & Beverage

Life Sciences

Applicable Functions

Product Research & Development

Quality Assurance

Use Cases

Predictive Quality Analytics

Process Control & Optimization

Remote Control

Services

Cloud Planning, Design & Implementation Services

Software Design & Engineering Services

System Integration

Challenge

Arzeda needed a more efficient and less error-prone method to construct plasmids for producing designer proteins. The existing process was slow, resource-intensive, and prone to errors. The company faced a choice: either hire additional personnel to develop a new solution from scratch or integrate proven technologies from trusted vendors into a seamless, high-throughput DNA assembly platform.

About Customer

Arzeda is a biotechnology company that designs and creates proteins for various industries, including life sciences, food, and chemicals. The company focuses on delivering important molecules by testing thousands of protein-producing plasmids. Arzeda aims to provide cost-effective and sustainable production of value-added specialty chemicals and ingredients. The company leverages computational protein design to build novel enzymes and develop new pathways, unlocking new opportunities for specialty chemicals, advanced materials, and health and nutrition products.

Solution

Arzeda opted to integrate proven technologies from trusted vendors to create a seamless, high-throughput DNA assembly platform. They combined Twist Bioscience’s high-quality DNA fragments, TeselaGen’s DNA assembly design and laboratory automation software, and Labcyte’s Echo Liquid Handler. This integrated solution increased productivity, reduced consumable use, generated more accurate plasmid designs, and lowered costs. Twist Bioscience’s silicon-based DNA synthesis platform quickly and affordably produced high-quality synthetic DNA, which Arzeda combined into plasmids using sophisticated DNA assembly methods. TeselaGen’s software automated the process of DNA assembly, determining the best way to put plasmids together and which DNA fragments should be synthesized by Twist. The Labcyte Echo Liquid Handler used sound waves to move nanoliter-sized liquid droplets, making the process more efficient and reducing costs.

Impact #1	The integrated platform allowed Arzeda to increase the number of enzymes built and tested by about 10x.
Impact #2	The process became more predictable, reducing the time spent reworking plasmids and minimizing wasted design and synthesis time.
Impact #3	The Echo Liquid Handler’s use of sound waves for liquid transfer eliminated the need for pipettes, reducing the risk of cross-contamination and saving on disposables.

Impact #1

The integrated platform allowed Arzeda to increase the number of enzymes built and tested by about 10x.

Impact #2

The process became more predictable, reducing the time spent reworking plasmids and minimizing wasted design and synthesis time.

Impact #3

The Echo Liquid Handler’s use of sound waves for liquid transfer eliminated the need for pipettes, reducing the risk of cross-contamination and saving on disposables.

Benefit #1	Arzeda expects to increase efficiency to a hundredfold by the end of 2019.
Benefit #2	The integrated platform allowed Arzeda to increase the number of enzymes built and tested by about 10x.

Benefit #1

Arzeda expects to increase efficiency to a hundredfold by the end of 2019.

Benefit #2

The integrated platform allowed Arzeda to increase the number of enzymes built and tested by about 10x.

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Overview

Building a Better DNA Assembly Line

Operational Impact

Quantitative Benefit