Case Studies Blueprint and the LifeArc Ideas Factory

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	Blueprint and the LifeArc Ideas Factory

Blueprint and the LifeArc Ideas Factory

Technology Category	Application Infrastructure & Middleware - Data Visualization Application Infrastructure & Middleware - Database Management & Storage Platform as a Service (PaaS) - Data Management Platforms
Applicable Industries	Healthcare & Hospitals Life Sciences
Applicable Functions	Product Research & Development Quality Assurance
Use Cases	Predictive Quality Analytics Root Cause Analysis & Diagnosis Virtual Prototyping & Product Testing
Services	Data Science Services Software Design & Engineering Services
Challenge	LifeArc, a UK medical research charity, is dedicated to transforming early-stage science into medical breakthroughs. The organization has a diverse range of scientific activities, from small molecules to engineered antibodies, which generates a variety of data types. This data is stored in operational databases and needs to be accessible for visualization and analytics. LifeArc also collaborates with a number of external organizations, adding to the complexity of the data sources. The challenge was to create an informatics system that could handle this complexity and streamline workflows, while also facilitating the process of ideation, which had historically been separated from informatics. Read More
About Customer	LifeArc is a UK-based medical research charity that has been bridging the gap between the lab and the patient for over 25 years. The organization provides scientific know-how, technology transfer expertise, and funding to help turn promising early-stage science into medical breakthroughs that transform lives. LifeArc has a strategy of 'making life science life changing' and partners with academics, industry, charities, and patients to transform the way diseases are identified and treated. The organization is committed to investing up to £1.3 billion (approx. $1.75B) by 2030 to advance lab-based scientific discoveries into the next generation of diagnostics, treatments, and cures. Medicines developed from LifeArc's humanized antibodies are already helping patients with a range of conditions, from cancer and Crohn's disease to multiple sclerosis and rheumatoid arthritis. A further eight potential medicines are in clinical trials. Recently, as part of the UK's Therapeutics Antibody Taskforce, LifeArc helped screen over 600 antibodies to create a Covid-19 'antibody cocktail'. Read More
Solution	LifeArc leveraged Dotmatics' suite of tools to develop a comprehensive Design Make and Test platform, termed the 'LifeArc Ideas Factory'. The informatics system was built to provide data via Dotmatics Browser, with Blueprint and Browser being well connected. Microservices were used to generate calculated properties, machine learning or models that could be injected into the Blueprint environment. Dotmatics Bioregister was used for registering all biologics to ensure entity uniqueness and protect intellectual property. The Ideas Factory allowed scientists to use Dotmatics Blueprint in a concerted manner, bringing all data to the modelling suite. The system also allowed for the capture of all ideas, whether they came from a modelling suite, cheminformatics platform, or a virtual reality (VR) environment. In the VR environment, researchers could combine data from Blueprint and molecular models and track the results in an ideas database. Dotmatics Chemselector was also used in VR, allowing chemists to search publicly available databases for analogues or matched-pairs, pull them into VR, do some modelling and use Blueprint for further analysis. Read More Log in to view content
Contents

Technology Category

Application Infrastructure & Middleware - Data Visualization

Application Infrastructure & Middleware - Database Management & Storage

Platform as a Service (PaaS) - Data Management Platforms

Applicable Industries

Healthcare & Hospitals

Life Sciences

Applicable Functions

Product Research & Development

Quality Assurance

Use Cases

Predictive Quality Analytics

Root Cause Analysis & Diagnosis

Virtual Prototyping & Product Testing

Services

Data Science Services

Software Design & Engineering Services

Challenge

LifeArc, a UK medical research charity, is dedicated to transforming early-stage science into medical breakthroughs. The organization has a diverse range of scientific activities, from small molecules to engineered antibodies, which generates a variety of data types. This data is stored in operational databases and needs to be accessible for visualization and analytics. LifeArc also collaborates with a number of external organizations, adding to the complexity of the data sources. The challenge was to create an informatics system that could handle this complexity and streamline workflows, while also facilitating the process of ideation, which had historically been separated from informatics.

About Customer

LifeArc is a UK-based medical research charity that has been bridging the gap between the lab and the patient for over 25 years. The organization provides scientific know-how, technology transfer expertise, and funding to help turn promising early-stage science into medical breakthroughs that transform lives. LifeArc has a strategy of 'making life science life changing' and partners with academics, industry, charities, and patients to transform the way diseases are identified and treated. The organization is committed to investing up to £1.3 billion (approx. $1.75B) by 2030 to advance lab-based scientific discoveries into the next generation of diagnostics, treatments, and cures. Medicines developed from LifeArc's humanized antibodies are already helping patients with a range of conditions, from cancer and Crohn's disease to multiple sclerosis and rheumatoid arthritis. A further eight potential medicines are in clinical trials. Recently, as part of the UK's Therapeutics Antibody Taskforce, LifeArc helped screen over 600 antibodies to create a Covid-19 'antibody cocktail'.

Solution

LifeArc leveraged Dotmatics' suite of tools to develop a comprehensive Design Make and Test platform, termed the 'LifeArc Ideas Factory'. The informatics system was built to provide data via Dotmatics Browser, with Blueprint and Browser being well connected. Microservices were used to generate calculated properties, machine learning or models that could be injected into the Blueprint environment. Dotmatics Bioregister was used for registering all biologics to ensure entity uniqueness and protect intellectual property. The Ideas Factory allowed scientists to use Dotmatics Blueprint in a concerted manner, bringing all data to the modelling suite. The system also allowed for the capture of all ideas, whether they came from a modelling suite, cheminformatics platform, or a virtual reality (VR) environment. In the VR environment, researchers could combine data from Blueprint and molecular models and track the results in an ideas database. Dotmatics Chemselector was also used in VR, allowing chemists to search publicly available databases for analogues or matched-pairs, pull them into VR, do some modelling and use Blueprint for further analysis.

Impact #1	Streamlined workflows for R&D scientists, allowing them to access all their data for visualization and analytics.
Impact #2	Enabled the capture of all ideas, whether they came from a modelling suite, cheminformatics platform, or a virtual reality environment.
Impact #3	Provided a comprehensive Design Make and Test platform, termed the 'LifeArc Ideas Factory', leveraging available informatics and modelling tools.

Impact #1

Streamlined workflows for R&D scientists, allowing them to access all their data for visualization and analytics.

Impact #2

Enabled the capture of all ideas, whether they came from a modelling suite, cheminformatics platform, or a virtual reality environment.

Impact #3

Provided a comprehensive Design Make and Test platform, termed the 'LifeArc Ideas Factory', leveraging available informatics and modelling tools.

Benefit #1	Investing up to £1.3 billion (approx. $1.75B) by 2030 to advance lab-based scientific discoveries into the next generation of diagnostics, treatments, and cures.
Benefit #2	Helped screen over 600 antibodies to create a Covid-19 'antibody cocktail'.
Benefit #3	Eight potential medicines are in clinical trials.

Benefit #1

Investing up to £1.3 billion (approx. $1.75B) by 2030 to advance lab-based scientific discoveries into the next generation of diagnostics, treatments, and cures.

Benefit #2

Helped screen over 600 antibodies to create a Covid-19 'antibody cocktail'.

Benefit #3

Eight potential medicines are in clinical trials.

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Overview

Blueprint and the LifeArc Ideas Factory

Operational Impact

Quantitative Benefit